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February 2015

Golden retrievers help cancer research

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Our paper on two common cancers in golden retrievers is published in PLoS Genetics! Canine B-cell lymphoma and hemangiosarcoma are malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma. We were part of a large group of scientists, led by Noriko Tonomura and Kerstin Lindblad-Toh, that idenitifed genetic variants associated with a risk of developing these diseases in golden retrievers, and showed they appear to affect pathways involved in T-cell mediated immune response in the tumor. Thank you to all the golden retrievers (and their owners) who made this work possible!