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karlssonlab

Happy New Year from the Karlsson Lab!

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(click here for larger version)

We began 2016 as a little group with big ideas for the future of science. In addition to our ongoing work on infectious diseases, our citizen-supported research project “Darwin’s Dogs” had just launched, and we were eager to see how it would be received. Now, as we greet 2017, we find ourselves having become not quite so little. Over the past year, we’ve welcomed the Broad’s Vertebrate Genomics group, added our first three graduate students, and signed up nearly 12,000 Darwin’s Dogs. The number of species we study has grown by nearly 100 fold, and now covers everything from the Aye-aye to the White Rhino (we should really consider adding a Zebra). Meanwhile, our dog-owning citizen scientists have answered over one million survey questions. As we look back over the last year, we are incredibly grateful to everyone who has helped and supported us in this transition. We have experienced collaborative science at its very best.

In this year’s card, we pay homage to the scientists and explorers that came before us, and on whose shoulders we stand. As we venture forth into a new year of discoveries, may we continue in their intrepid spirit.

Our best wishes for a 2017 filled with exploration,

The Karlsson Lab

P.S. You can sign your dog up – whether purebred or pure mutt – at DarwinsDogs.org!

Darwin’s Dogs +++

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We are excited to announce the joining of two great projects in dog genetics: the Dog Genome Project at the Broad Institute and the Karlsson Lab’s Darwin’s Dogs Project at the University of Massachusetts Medical School.

What does this mean?

None of the ongoing research projects at the Broad Institute or at Darwin’s Dogs will end. We will continue our research, started at the Broad, into cancer and other diseases, as well as our Darwin’s Dogs projects studying how genetics shapes behavior and can sometimes lead to psychiatric diseases.

If you have enrolled your dog in one study can you participate in the other?

Definitely! Over the next few months, we will be uniting these two projects under a single website, making it easier for you to participate, and easier for us to keep you updated on how our research is going. To do this successfully, we need your help.

  • If your dog is enrolled in the Dog Genome Project at the Broad Institute, you will receive an email soon asking if you would like to enroll in Darwin’s Dogs.
  • If you have already signed up for Darwin’s Dogs, you will receive an email in the next few months asking if you would like to enroll in any of the disease research projects at the Broad Institute.
  • Finally, if your dog is already enrolled both at the Broad Institute and at Darwin’s Dogs, please email us at info@darwinsdogs.org and let us know so we can combine your information.

Haven’t either project joined yet? Join today! 

Happy Holidays from us!

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Happy holidays from the Karlsson Lab! One year in, we have grown to five lab members (some may remember last year’s solo holiday card). It has been a busy year, capped off by the launch of our citizen-science dog genetics project Darwin’s Dogs. It seemed only fitting that this year’s card, below, be inspired by Spaceballs, the first (only?) movie to star a Mawg (half-man, half-dog).

May the Schwartz be with you in 2016.


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Is your dog AMAZING?

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Screen Shot 2015-10-13 at 6.53.51 PMOur dog behavior questionnaire site is now live! We’ve had an incredible response in the first week – thank you to everyone who has joined up.

Do you have a dog? Join the project at www.darwinsdogs.org. There is no cost for participation – and we’ll let you know about anything we find out.

We’re studying how the dog genome has changed as dogs evolved from wolves to beloved companions and work partners. If we can understand how genetic changes can lead to behavior differences — even for normal behaviors — we will have new insight into psychiatric and neurological diseases in dogs and people.

Dr. Diane Genereux joins the Karlsson lab!

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Jesse keenly observes dog behavior at the Somerville Dog Festival

Dr. Diane Genereux has joined the Karlsson Lab, doubling the postdoc ranks! Diane has an impressive research background in evolution, epigenetics, and mathematical modeling and is now delving into the complexity of bioinformatics. While not exploring the genetics of cholera susceptibility, she acts as lab photographer – and captured some great photos of the Darwin’s Dogs launch in Somerville, MA in September.

Pawprints of evolution

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Darwin's DogsOur new dog genetics project is launching on Sunday, September 13 at the Somerville Dog Festival. Do you own a dog? We need your help!

You can visit our booth between 10 am and 3 pm on Sunday at Trum field in Somerville, Massachusetts. We’ll be enrolling dogs, and handing out frisbees and bandannas.

The Somerville Dog Festival is a fun (and free!) event for dogs and people. This year (at 1 pm) they will try to break a World Record.

If you can’t make it to Somerville, don’t worry! You can also join the Darwin’s Dogs pack online.

There is no cost to you. We’ll ask you to tell us about your dog’s behavior and personality using shortSurvival of furriest questionnaires on our website, and then send you an easy-to-use kit to collect a saliva sample from your dog. Using the saliva samples from many dogs, we will look for differences in DNA connected to particular personality traits or behaviors.

We want to understand how dog DNA changed as dogs went from living in the wild to being part of our families. If we can understand how genetic changes can lead to behavior differences — even for normal behaviors — we hope to get new insight into psychiatric and neurological diseases in dogs and people.

Dr. Jesse McClure joins the Karlsson Lab!

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Jesse even taught his parrot Auggie to play Scrabble.

Dr. Jesse McClure joined the Karlsson lab this summer as our first postdoc! Jesse will be working on a pet dog genetic mapping project we’ve dubbed “Darwin’s dogs”. Jesse has an impressive background in animal behavior, starting as a military working dog trainer, and recently finished his doctorate in neuroscience and behavior at the University of Massachusetts Amherst.

Computational Postdoc Wanted

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Apply here

The Karlsson Lab in the Program Bioinformatics and Integrative Biology at the University of Massachusetts Medical School is looking for an exceptional postdoctoral candidate to lead our work developing innovative new computational methods for studying human evolution in collaboration with scientists at the Broad Institute. The Karlsson lab uses the distinctive patterns left by ancient evolutionary events to investigate how our immune system combats infectious diseases, and how we can improve treatments and vaccines for diseases, like cholera, that affect millions of people every year.

Job description:

Computational postdoctoral fellow who can conceive and develop algorithms and analysis approaches for integrating diverse types of data and identifying functionally important genes and regions. A highly competitive salary and excellent benefits package will be provided commensurate with experience.

Key Responsibilities:

  • Devise new algorithms and approaches to analyze natural selection, association and other types of whole genome data.
  • Test methods on simulated data modeling a range of human population histories
  • Work closely with experimentalists to validate methods using real genomic datasets
  • Optimize successful algorithms for use by the broader scientific community

Qualifications:

This position is an opportunity for experienced computer scientists to work at the cutting edge of medical genomics. The ideal candidate will have a strong quantitative research background and practical experience working with large, complex data sets, developing new analysis methods, and producing high quality published work. Experience in machine learning, signal processing and/or data mining is preferred. A background in human genetics and computational biology is helpful, but not required.

The candidate will also have shown the ability to solve complex problems individually and as part of a team; have excellent oral and written English communication skill; and have experience developing software in one or more programming languages.

Preference will be given to candidates with degrees in computer science, bioinformatics, statistical genetics or other applied quantitative fields.

Apply here

Golden retrievers help cancer research

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Our paper on two common cancers in golden retrievers is published in PLoS Genetics! Canine B-cell lymphoma and hemangiosarcoma are malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma. We were part of a large group of scientists, led by Noriko Tonomura and Kerstin Lindblad-Toh, that idenitifed genetic variants associated with a risk of developing these diseases in golden retrievers, and showed they appear to affect pathways involved in T-cell mediated immune response in the tumor. Thank you to all the golden retrievers (and their owners) who made this work possible!